It is deduced that through the modulation of the therapeutic target genes ADORA1, HCAR2, and GABBR1, present in the cAMP signaling pathway, phytoconstituents present in CS could contribute to the maintenance of glucose homeostasis, the proper functioning of pancreas and pancreatic beta-cells, as well as the prevention of T2DM-associated secondary complications. Here, GABBR1 is linked to type 2 diabetes mellitus.