Interestingly, mice treated with exosomes secreted by Ox-LDL-treated human umbilical vein endothelial cells lead to hyperlipidemia, local inflammation, and the formation and worsening of AS plaques by upregulating the expression of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) [97]. The gene discussed is MALAT1; the disease is hyperlipidemia.