In an attempt to understand how the changes in SIRT1 and SIRT2 levels may affect the vulnerability of the neurons to a neurotoxic insult, SH-SY5Y neuroblastoma cells were transfected with empty vector, flag-tagged SIRT1 or SIRT2, and then treated with Aβ42 oligomers. The gene discussed is SIRT1; the disease is neuroblastoma.