TLR2 and myeloid sarcoma: In humans, markers of the primed state of neutrophil granulocyte activity, like their elevated number, reduced apoptotic activity, higher expression of TLR-2, fMLP receptor, IL-8 receptor and CD43, enhanced degranulation and increased levels of neutrophil extracellular traps in serum, have also been documented, depicting a complex autoreactive status of the CNS in MS and fueling intensive investigations for factors involved in the dysregulation of immune cells upon Multiple Sclerosis [87].