Moreover, the induction of genes encoding chemokines CXCL1 and CXCL2, which are known to be upregulated in the CNS during MS and are believed to orchestrate the chemotaxis of neutrophil granulocytes to the CSF and CNS in EAE, has been shown to be mediated by encephalitogenic CD4+ TH17 cells, the core players of MS pathogenesis [86]. This evidence concerns the gene CD4 and myeloid sarcoma.