The role of autoreactive immune cells in the pathogenesis of the neuroinflammation in the CNS of MS patients has been supported by the findings that myelin basic protein-activated CD5+ T cells are able to provoke experimental allergic encephalomyelitis in healthy mice and that HLA-DR-positive macrophages are also present in the CSF of MS patients [31,32]. Here, CD5 is linked to myeloid sarcoma.