For example, mutations in TBP (spinocerebellar ataxia type 17; SCA17), ATN1 (dentatorubral-pallidoluysian atrophy; DRPLA), JPH3 (Huntington disease-like 2; HDL2), C9orf72 (Frontotemporal dementia and/or Amyotrophic lateral sclerosis; FTD/ALS1), and FXN (Friedreich ataxia) can all cause Huntington’s disease-like syndromes [15]. Here, JPH3 is linked to amyotrophic lateral sclerosis.