MTOR and focal epilepsy: While most genetic epilepsies are associated with generalized seizures, several genes have been identified as causative of focal epilepsies, such as NPRL2, NPRL3 [42], and DEPDC5 [43], genes involved in regulating the mammalian target of rapamycin (mTOR) pathway, as well as FLNA (focal seizures due to unilateral or bilateral periventricular nodular heterotopia) and LGI1 (focal seizures with auditory features).