CD4 and neoplasm: BPDCN has long been disputed in an attempt to understand its actual origin and this classification uncertainty has resulted in different types of previously given nomenclatures such as Blastic NK-cell Lymphoma (obsolete), agranular CD4+ NK leukemia (also obsolete term), blastic NK leukemia/lymphoma (obsolete) and agranular CD4+ CD56+ hematodermic neoplasm/tumor [7].