Recent gene expression profiling studies have made it possible to understand that PDCs are more closely related to the myeloid lineage rather than to the lymphoid line [7] and further data obtained from TCF4 (E2-2) ChIP-se data and gene expression changes following TCF4 knock-down revealed the similarity between normal PDCs, BPDCN cell lines and primary BPDCN, distinguishing this latter one from AML lines [7]. Here, TCF4 is linked to acute myeloid leukemia.