Sarcomeric gene variants in MYBPC3 (myosin-binding protein), MYH7 (β-myosin heavy chain), TNNI3 (troponin I), TNNT2 (troponin T), TNNC1 (troponin C) [33], ACTC1 (α-cardiac actin) [31], TPM1 (tropomyosin 1), MYL3 and MYL2 (myosin light chain) [34] have been associated with both HCM and RCM [4,35,36]. This evidence concerns the gene TPM1 and cardiomyopathy, familial restrictive, 1.