FLNC and cardiomyopathy, familial restrictive, 1: FLNC missense variants can cause early-onset RCM associated with variable degrees of skeletal myopathy, combined with mild CK elevation and supraventricular arrhythmias, whereas FLNC truncating variants have been found in patients with an ACM/DCM phenotype characterized by a high risk of ventricular arrhythmias [48].