In addition, the qRT-PCR results demonstrated increases in two renal fibrosis markers, i.e., vimentin and FSP-1, in the SAMP1-50wk group (Figure 1C,D) plus a decrease in the expression of podocin (a glomerulosclerosis marker) in these mice (Figure 1E). Here, NPHS2 is linked to glomerulosclerosis.