In the study conducted by Kammerer-Jacquet SF et al., according to the FISH analysis, the 19 ALT/WDLS had MDM2 amplification and 14 had CDK4 co-amplification, and in the benign tumors, the expression of the two markers was negative in 43/44 cases [26]. The gene discussed is CDK4; the disease is benign neoplasm.