PLOD1 and osteoporosis: In addition, target interaction network analysis by network-based visual analysis (miRNet) showed that five genes (GAPDH, PLOD1, LMNA, WDR1, and P4HB) with five miRNAs (hsa-let-7a/b-5p, hsa-let-7b-5p, hsa-mir-16-5p, hsa-mir-18a-5p, and hsa-mir-192-5p) were associated with osteoporosis by DisGeNET (Figure 2).