Four target genes (LMNA, MSN, PDCD6IP, and GAPDH) with five miRNAs (hsa-let-7a-5p, hsa-let-7b-5p, hsa-mir-15a-5p, hsa-mir-26a-5p, and hsa-mir-23b-3p) were associated with the pathway in osteoarthritis according to the results of the miRNet network analysis. The gene discussed is LMNA; the disease is osteoarthritis.