P4HB and osteoporosis: In addition, DisGeNET database analysis of gene–disease associations showed seven genes (TLN1, VCL, ENO1, CAP1, P4HB, GAPDH, and WDR1) in the functional annotation clustering of DAVID informatics and seven genes (GAPDH, P4HB, LMNA, WDR1, PLOD1, MSN, and PDCK6IP) in the miRNet analytics platform among the 64 spots associated with bone-related diseases, such as osteoarthritis and osteoporosis (Figure 1B and Figure 2).