The expression of C1QTNF6 and PROM2 was also quantified by qRT-PCR and both genes were found to be in PB68-RETC634Y LPCs as compared to PB68-WT LPCs indicating that RET pathway activation is associated with the overexpression of these two NSCLC poor prognosis markers (Figure 5F). The gene discussed is PROM2; the disease is non-small cell lung carcinoma.