Enrichment based on this atlas reveals that RET-dependent repressed signature in NSCLC may affect several normal lung cell subpopulations such as type I alveolar epithelial cells (AT1s), airway smooth muscle cells, alveolar fibroblasts, pericytes, IGSF21 positive dendritic cells, and vascular smooth muscle cells (green bars, Figure 2F). This evidence concerns the gene IGSF21 and non-small cell lung carcinoma.