However, in contrast to the tumor versus normal tissue comparisons, CDK12 mRNA expression was reduced in the tumor cell populations with low PD-L1 mRNA expression and a high E4/E6 mRNA ratio compared to the tumor populations with high PD-L1 mRNA expression and a low E4/E6 mRNA ratio, and this was particularly evident for LUAD (Figure 4E). The gene discussed is CD274; the disease is neoplasm.