Moreover, the Mn-induced NLRP3-CASP1 inflammasome pathway in mouse neuroblastoma (N2a) cells (250, 500, and 1000 μM Mn for 24 h and 48 h) and Mn-exposed male SD rats (25 mg/kg Mn, 30 days) mediates KH-type splicing regulatory protein (KHSRP) expression [121]. The gene discussed is KHSRP; the disease is neuroblastoma.