Therefore, this study aimed to address the effect of a psoriasis-like inflammatory milieu induced by a novel cytokine mixture (referred to as ‘CytoMix’) including IL-17A, IL-22, TNF-α, IFN-γ, and keratinocyte growth factor/fibroblast growth factor 7 (KGF/FGF7), on healthy human epidermal KCs at a lower, more in vivo-relevant cytokine concentrations (referred to as ‘mild inflammation’). This evidence concerns the gene IL17A and psoriasis.