SPI1 and Alzheimer disease: Additionally, the CD11b marker was also reported in postmortem brain tissue of healthy controls and AD cases, specifically as a biomarker of HAM/DAM phenotypes in association with a higher expression of TMEM119 and P2RY12 and upregulation of APOE, ABCA7, GPR141, PTK2B, SPI1, ZYX, MS4A6A, MS4A4A, and NME8 genes [102,125,148].