TMEM119 expression was also used as a marker of senescent/dystrophic human microglia associated with a downregulation of GPR34, RASAL3, SASH3, ADORA3, CPED1, CIITA, IGSF6, LY86, LAPTM5, and P2RY13 genes, during aging; instead, ACY3, ALOX5AP, and TLR7 genes are upregulated in AD [215]. This evidence concerns the gene IGSF6 and Alzheimer disease.