The premature aging Hutchinson-Gilford progeria syndrome (HGPS or Progeria) is characterized by the occurrence of a C-to-T silent mutation (LMNA c.1824 C > T, p.Gly608Gly) in exon 11 of the LMNA gene [113], encoding for an intermediate filament protein critical for maintenance of the nuclear envelope. This evidence concerns the gene LMNA and progeroid syndrome.