WDR45 and neurodegeneration with brain iron accumulation 5: It should be noted that static encephalopathy of childhood with neurodegeneration in adulthood (SENDA), a human neurodegenerative disorder caused by iron deposition in the brain, which presents with nonprogressive intellectual disability in early childhood and rapidly progressive extrapyramidal symptoms and dementia in adulthood, is known to be caused by genetic mutations in Wipi4 (homologous gene of Wipi3) [27].