The naturally expressed effective miRNA sponge mentioned earlier, CDR1as, is reported to play a role in diabetic cardiomyopathy (DCM) by modulating the ubiquitination of mammalian sterile 20-like kinase 1 (MST1), leading to the inhibition of MST1 expression and decreased the expression of downstream effector proteins of the Hippo-signaling pathway, including LATS2 and phosphorylated Yes-associated protein (YAP), in DCM mouse cardiac tissues and high-glucose-treated mouse cardiomyocytes [140]. This evidence concerns the gene YAP1 and familial dilated cardiomyopathy.