In vitro experiments using the H358 a non-small cell lung cancer cell line, which lacks the expression of endogenous p53, showed that DP3-p53 could successfully induce G1 arrest, and apoptosis, and introduce and transcribe the p53 gene in the bronchial epithelium of transgenic mice lacking the p53 gene. This evidence concerns the gene TP53 and non-small cell lung carcinoma.