RTEL1 and hypotrichosis 1: In this study, we have set up experiments to further explore the potential roles of RTEL1 in nucleocytoplasmic exchanges, specifically its interactions with major nuclear import receptors such as importin α (official name KPNA2) and importin β (official name KPNB1) [24,25,26], and explored how these roles may be connected to nuclear envelope deformations, which appear to be prevalent in HHS patients’ cells (this study).