It has been reported that total ceramide levels and larger species of ceramides (>40 total carbons) like Cer[NH], Cer[EOS], Cer[NP], Cer[EOH], and Cer[EOP] are expressed at significantly lower levels, whereas smaller species (<40 total carbons) are expressed at higher levels in AD skin compared to healthy counterparts [19]. The gene discussed is CBLN1; the disease is Alzheimer disease.