ADM and neoplasm: TAMs are densely organized in hypoxic regions of the tumor, where the same hypoxic microenvironment stimulates cells to overexpress transcription factors such as hypoxia-inducing factor (HIF) or other molecules such as platelet-derived growth factor (PDGF), adrenomedullin (ADM), matrix metalloproteinase (MMPs) and transforming growth factor (TGF-β) [14,15].