CHCHD10 and amyotrophic lateral sclerosis: In contrast, CHCHD10R15L and CHCHD10S59L brains exhibited > 2.3-fold reductions in red-only puncta compared to CHCHD10WT brains (Figure 1b,c), indicating that these ALS/FTD-linked CHCHD10 mutations disrupt mitophagy flux in the brain.