CHCHD10 is a component of the mitochondrial contact site and cristae organizing system (MICOS) complex [11], which stabilizes the MICOS complex through its core protein MIC60, whereas ALS/FTD-linked CHCHD10 mutations (R15L and S59L) destabilize the MIC60 complex [20]. The gene discussed is CHCHD10; the disease is amyotrophic lateral sclerosis.