Again, we observed markedly more PARL pulldown in M2 Flag-antibody immune complexes of CHCHD10WT-transfected cells compared to those transfected with ALS/FTD-linked mutants (R15L and S59L) (Supplemental Figure S2), indicating that CHCHD10WT forms a more stable complex with PARL than CHCHD10R15L and CHCHD10S59L. The gene discussed is PARL; the disease is amyotrophic lateral sclerosis.