Indeed, 10-month-old CHCHD10R15L and CHCHD10S59L mice accumulate substantial pathology, and both CHCHD10 and TDP-43 aggregates associated with mitochondria and exhibited electrophysiological and behavioral deficits that were pathologically pertinent to ALS–FTD [24]. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.