Studies employing [11C]PK11195 (i.e., TSPO imaging) revealed increased binding in the thalamus, putamen, and pallidum when comparing PSP patients with HC, and significant correlations were found between [11C]PK11195 binding and cognitive performance, as well as disease severity, highlighting its potential as a diagnostic and monitoring marker for PSP [99,103]. Here, TSPO is linked to supranuclear palsy, progressive, 1.