For example, EV-delivered miR-34a-5p (miR-34a), which targets the cyclin-dependent kinase inhibitor 1A (p21Cip1/Waf1), was implicated as a mechanism by which senescent chondrocytes from osteoarthritis patients induce senescence in nearby chondrocytes [60]. This evidence concerns the gene CDKN1A and osteoarthritis.