ADIPOQ and nutritional deficiency disease: Physical signs and symptoms/clinical manifestations of frailty are as follows: changes in anthropometric measurements; sarcopenic obesity; malnutrition; decrease in the level of physical activity; decrease in hand grip strength; exhaustion; unintentional weight loss; changes in gait; changes in cardiac autonomic modulation; poor sleep quality; comorbidities; anorexia; increase in estradiol levels; increase in levels of plasma proteins, such as adiponectin and inflammatory glycoproteins; and use of auxiliary devices [22].