Ghorpade et al. reported that the secretion of DPP4 from hepatocytes triggered adipose tissue inflammation and insulin resistance, while silencing of DPP4 reduced them; however, this effect was not produced with ST, indicating a diverse mode of action [24] Previous studies reported the hepatoprotective activity of ST in a mouse model of steatohepatitis via modulation of oxidative stress, lipid metabolism, and inflammatory mediators [25,26]. The gene discussed is DPP4; the disease is Insulin resistance.