The in vivo fluorescence results confirmed effective targeting and accumulating of P-Y/G@NHs at the tumor site in nude mice to enhance the radiosensitivity of target tumors without significant side effects or immune toxicity, which highlighted the potential application of P-Y/G@NHs in radiotherapy of NSCLC cells by repressing the PI3K/AKT signaling pathway (Figure 2) [68]. The gene discussed is AKT1; the disease is non-small cell lung carcinoma.