AKT1 and non-small cell lung carcinoma: In general, dextran-based radioconjugates can enhance the therapeutic effect of radiotherapy, and dextran uptake further accompanies the activation of the phosphatidylinositol 3-kinase/protein kinase B (PI3K/AKT) signaling pathway upon entry of viruses into cells [65,66], which can enhance the sensitivity of NSCLC radiotherapy [67].