It encompasses a wide range of inflammatory demyelinating disorders of the CNS—acute disseminated encephalomyelitis (ADEM), brainstem or cortical encephalitis, unilateral or bilateral optic neuritis, chronic relapsing inflammatory optic neuropathy, transverse myelitis, and aquaporin-4 IgG-negative neuromyelitis optica spectrum disorders [103]. This evidence concerns the gene AQP4 and acute disseminated encephalomyelitis.