In addition, although studies have shown that speech disturbances, voice disorders, cough, and breathing abnormalities are positively associated with certain mental illnesses [1,2,3,4,5,6], beyond age, sex, smoking, body mass index (BMI), and ACE Inhibitors [2,4], these studies did not adjust for the five important confounders (gastroesophageal reflux disease, asthma, allergies, chronic sinusitis, and hypertension) we considered in this study. Here, ACE is linked to chronic rhinosinusitis.