APOE and lymphedema: Cluster 0, defined by expression of adipocyte markers such as FABP4, FABP5, APOE, and CD36 was more abundant in healthy samples, while cluster 1, defined by FBN1, PRG4, and ADAMTS5 expression, was more abundant in lymphedema; the relative proportions of the other clusters were unchanged between tissue types (Figure 3C).