STAT3 and Netherton syndrome: Furthermore, LINC02541 was consistently downregulated in psoriasis (P = 2.6 × 10–20, FC = 0.54), AD (P = 4.0 × 10–10, FC = 0.54), and Netherton syndrome (P = 1.0 × 10–3, FC = 0.55), while STAT3 was upregulated in all 3 diseases.