STAT3 and inflammatory skin disease: Another lncRNA of interest, LINC02541, predicted by our machine-learning approach to be involved in the IFN-γ pathway (mean score = 0.822), was significantly negatively correlated (r = –0.628, P = 9.5 × 10–93) with STAT3, a gene known to be involved in the pathogenesis of psoriasis (49), among other inflammatory skin diseases.