One had a personal history of BRCA-associated cancer, pancreatic acinar cell carcinoma diagnosed aged in their seventies and for which they were recruited to the 100KGP cancer arm; this individual’s mother was diagnosed with breast cancer aged in her seventies, and child with bile duct cancer aged in their forties (the BRCA2 variant was not reported as a primary finding). The gene discussed is BRCA2; the disease is breast cancer.