Conversely, multiple genes such as CHIL3, epithelial cellular adhesion molecule (EpCAM), apolipoprotein E (APO‐E), COUP transcription factor 1 (COUP‐TF1 or EAR3), midline‐1 (MID1), extracellular matrix protein 1 (ECM1) and GKN3 were found to be under‐expressed simultaneously in the cancer cells and stroma of treated KPC mice tissue. Here, ECM1 is linked to cancer.