Several immune mediators that drive osteoclastogenesis in favor of net bone loss, including interferon (IFN) γ, IL6, TNFα, and IL17A, have also been implicated in the development of PTSD and comorbid conditions (Neigh and Ali, 2016; Passos et al., 2015; Wang et al., 2017). The gene discussed is TNF; the disease is post-traumatic stress disorder.