PAFAH1B1 and Cognitive impairment: The functional role of the platelet-activating factor acetylhydrolase 1B1 (PAFAH1B1) is related to cortical development, and previous studies documented that genetically modified mice with Pafah1b1 haploinsufficiency displayed defects in neuronal migration, cognitive deficits, epilepsy, and disorganization of some brain areas, including cortex and hippocampus, most likely associated with selective reductions of cortical GABAergic interneurons (Hirotsune et al., 1998; Paylor et al., 1999; Pleasure et al., 2000; Greenwood et al., 2009; Dinday et al., 2017).