Our previous studies have reported that Tau N368 fragment is produced by AEP-mediated cleavage and plays an important role in neurodegenerative diseases like AD and Parkinson’s disease (PD) (Zhang et al., 2014; Xiang et al., 2019; Ahn et al., 2020; Kang et al., 2020). Here, MAPT is linked to Alzheimer disease.