Recent studies reported that mammalian asparagine endopeptidase (AEP, gene name LGMN), a proteolytic enzyme, can cleave Tau at N255 and N368 residues and produce toxic truncated fragments which would promote Tau aggregation, leading to the exacerbation of AD-like pathologies in mice (Zhang et al., 2014). This evidence concerns the gene MAPT and Alzheimer disease.