EMT properties and cancer metastasis can be suppressed by downregulating YAP/TAZ (Najumudeen et al., 2021), and LYRIC, the positive regulator of EMT, can prevent cancer metastasis by inhibiting the expression of GPX4 and SLC3A2 to promote ferroptosis (Li et al., 2018). The gene discussed is WWTR1; the disease is cancer.