In this study, we further compared the mutational differences between high- and low-risk groups in 20 genes (TP53, CTNNB1, ALB, AXIN2, KEAP1, BAP1, NFE2L2, LZTR1, RB1, PIK3CA, KRAS, IL6ST, CDKN2A, ARID2, ARID1A, ACVR2A, NRAS, HISR1H1C, PTEN, and ERRFI1) that are predominantly mutated in HCC [25]. The gene discussed is PIK3CA; the disease is hepatocellular carcinoma.