RB1 and non-small cell lung carcinoma: Twelve of these mutated genes were found to be concordant with a large cohort study of BM from NSCLC: EGFR, TP53, KRAS, CDKN2A, STK11, PIK3CA, MYC, CDKN2B, KEAP1, NKX2-1, SMARCA4, and RB1 (Figure 2A).6 The same study also found NFKBIA, RICTOR, and NF1 to be frequently mutated; these genes were also identified in our cohort but were not in our top mutated genes.6 A meta-analysis found TP53, EGFR, KRAS, STK11, and EML4-ALK to be frequently mutated in NSCLC.21 We identified a similar pattern in our BM derived from NSCLC.