SCC shares many alterations with lung adenocarcinoma, but has specific somatic alterations including TP53, LRP1B, CDKN2A, PTEN, PIK3CA, KEAP1, MLL2, HLA-A, NFE2L2, NOTCH1, RB1, and PDYN. The gene discussed is KEAP1; the disease is lung adenocarcinoma.