A recent large cohort study found TP53, KRAS, CDKN2A, STK11, CDKN2B, EGFR, NKX2-1, RB1, MYC, and KEAP1 genes to be frequently mutated.6 This study also suggested different genomic profiles in the primary NSCLC compared to the BM.6 This evidence concerns the gene RB1 and non-small cell lung carcinoma.