The research team found that neurons in the brains of AD patients are activated to re-enter the active state of cell cycle after being damaged by oxidative stress (normal neurons are at rest), and at this time, more dephosphorylated tau protein will accumulate in the nucleus of neurons, limiting the cells in the S phase, thus preventing neurons from passing the S phase and apoptosis (Denechaud et al., 2023). Here, MAPT is linked to Alzheimer disease.