Besides, scientists used SIMOA technology to determine the plasma biomarkers of individuals with MCI, AD and cognitive normal (CU), and found that: Compared with CU, the levels of p-tau181, NFL and t-tau in AD dementia group were increased (p < 0.001), Aβ42/Aβ40 were decreased (p < 0.001), and Aβ42 was not changed. The gene discussed is MAPT; the disease is Alzheimer disease.