Lleo et al. (2019) collected CSF from 467 Alzheimer’s patients in 2019 for data analysis, and in contrast to previous findings in a study of longitudinal trajectories of CSF, the authors found that levels of three biomarkers, p-tau, t-tau and NFL, increased with age; compared to healthy controls, CSF in AD patients showed a t-tau decreased by 1% compared to healthy controls, while p-tau levels were not altered significantly. Here, NEFL is linked to Alzheimer disease.