MAPT and Alzheimer disease: For the identification of AD, p-tau was more accurate than t-tau protein, the Aβ42/p-tau ratio showed a higher predictive value, and the specificity and sensitivity of the combination of the two were 87 and 95%, respectively, so that the combination of biomarkers may have better diagnostic performance for AD (Hansson et al., 2018; McGrowder et al., 2021).