CAPN3 and hyperinsulinemic hypoglycemia, familial, 4: In the study by Rosales and Aguennouz, a reduced expression of miR 1 was seen, which worsens with the progression of muscle damage (LGMDR1) and in groups of secondary calpain deficiency (LGMDR1 and R2), respectively, which can help in the differential diagnosis, progression assessment, and in therapeutic studies (Rosales et al., 2013; Aguennouz et al., 2016).