Despite being related to fibrosis (Zanotti et al., 2015), the absence of miR -21, for example, when studied in congenital muscular dystrophy with laminin deficiency (LAMA2-CMD), which is not one of the LGMD subtypes, did not change the degree of dystrophy, indicating that it may not be involved in the development of fibrosis in this type of condition (Moreira Soares Oliveira et al., 2017). Here, LAMA2 is linked to limb-girdle muscular dystrophy.