We suspect that the softer ADAMTS10-mutant sclera is in part responsible for an improved IOP tolerance with slower progression of ONH atrophy and vision loss in Beagles with ADAMTS10-OAG compared to other glaucoma-affected canine breeds with comparable IOPs (Kuchtey et al., 2011; Park and Komaromy, 2021). This evidence concerns the gene ADAMTS10 and glaucoma.