TNF and SAPHO syndrome: IL‐6 has been found elevated in multiple pediatric CNO cohorts,(9, 10, 31) and also demonstrated higher concentrations in two studies on adults with SAPHO syndrome.(12, 14) The same holds true for IL‐8, TNF‐α, and IL‐17A, of which the previously published means of 36.41 pg/mL, 19–25.2 pg/mL, and 29–83 pg/mL vastly exceed those found in the current study.