ACP5 and type 2 diabetes mellitus: With regard to bone resorption, osteoclast number was not affected by T2DM and no differences were seen between SWR/J versus high‐TH and versus low‐TH (Fig. 4C) though an increase in TRAcP5b serum concentration was observed in the SWR/J (+58%, p < 0.001 vs. low‐TH and +40%, p = 0.002 vs. high‐TH) (Fig. 4D).