Male TH mice with T2DM had a significantly higher blood glucose along with elevated HbA1c and a lower serum concentration compared to TH mice without T2DM.[35] We did not assess the circulating levels of leptin nor the food intake, which would have been an intriguing aspect to elucidate any disparities that could potentially account for the observed impact on glucose tolerance. The gene discussed is LEP; the disease is type 2 diabetes mellitus.