Specifically, MTHFD2 was positively associated with most immune cells in THCA, PAAD, LIHC, KIRP, KIRC, KICH, and BLCA, whereas it was also negatively associated with most immune cells in some other cancers, such as UCEC, SARC, LUSC, and LUAD (Figure 1F). This evidence concerns the gene MTHFD2 and cancer.