MTHFD2 and adrenal cortex carcinoma: As shown in Supplementary Figure 1, MTHFD2 overexpression had a significant risky role for OS in ACC, BLCA, BRCA, HNSC, KICH, KIRC, KIRP, LUAD, MESO, PAAD, PRAD, and UCEC via univariate Cox regression, while the protective role was only found in GBM, LGG, and SKCM.