Furthermore, the heat shock protein 90 (HSP90) and dynamin-related protein 1 (DRP1) increase ROS production by regulating the expression of acyl-coenzyme A synthetase long-chain family member 4 (ACSL4) and mitochondrial morphology, leading to ferroptosis of gliomas in mice in vitro and in vivo (239). The gene discussed is DNM1L; the disease is glioma.