1)The use of ciglitazone promotes the production of ROS, leading to a decrease in GSH levels and cell death in glioma cells.2) SAS decreases GSH levels, induces ROS production, and promotes GBM cell death.3) Silibinin induces autophagy in glioma, resulting in the depletion of GSH, elevation of H2O2, and BNIP3-dependent nuclear translocation of AIF, ultimately leading to glioma cell death. This evidence concerns the gene AIFM1 and central nervous system cancer.