1) APOC1 reduces ferroptosis in GBMs by inhibiting KEAP1, promoting NRF2 nuclear translocation, increasing HMOX1 and NQO1 expression, and downregulating ROS.2) IR-TMZ can induce the generation of ROS, leading to the upregulation of NRF2 and promoting GBM recurrence. Blocking the activation of NRF2 can enhance the sensitivity of GBMs to chemoradiotherapy.3) S-guanylation of KEAP1 in glioma cells is induced by 8-nitro-cGMP, which leads to the activation of NRF2. Subsequently, the expression of HMOX1 is induced, while the level of H2O2 decreases, resulting in the survival of glioma cells. The gene discussed is APOC1; the disease is glioblastoma.