NFE2L2 and glioma: 1) Chaetocin sensitizes GBM cells to TRAIL-induced apoptosis by inducing ROS production and DNA damage. The deficiency of HMOX1 can enhance the sensitizing effect of chaetocin on TRAIL.2) Overexpression of NRF2 can increase HMOX1 expression, reduce ROS, reduce the cytotoxicity of carmustine, and promote glioma cell survival.3) ATO promotes glioma cell damage and HMOX1 expression by inducing the production of ROS. Inhibitors of HMOX1 significantly increase glioma cell death and ROS generation induced by ATO.