In the absence of AD peptides, the LTP induction protocol led to reduced somatic EPSP from 183% to 45% as the hypofunction in GluN2B-NMDAR increased, i.e., as the proportion of active GluN2B-NMDAR was lowered from 1 to 0.2 (Figure 6A, gray columns). The gene discussed is GRIN2B; the disease is Alzheimer disease.