Molecular and subcellular models of AD pathophysiology focus on detailed description of complex biochemical interactions of APP processing, Aβ, tau, tangles, inflammation, intracellular Ca2+ concentration, and a network of proteins and phosphatases responsible for LTP and LTD induction (Pallitto and Murphy, 2001; Proctor and Gray, 2010; Anastasio, 2011, 2013, 2014; Schmidt et al., 2012; De Caluwé and Dupont, 2013; Kyrtsos and Baras, 2013; Ortega et al., 2013; Proctor et al., 2013). Here, APP is linked to Alzheimer disease.