MTOR and epilepsy: At the molecular level, hyperactivation of the mammalian target of rapamycin (mTOR) signaling pathway has been observed in several models of epilepsy (Zeng et al., 2009; Huang et al., 2010; Pun et al., 2012; Zhang and Wong, 2012) and inhibition of mTOR reduces seizure activity (Zeng et al., 2009; Huang et al., 2010).