In addition, lncRNAs may function as biomarkers and be a part of specific therapeutic strategies for CAD.[77,78] For example, the death of macrophages and vascular endothelial cells in atherosclerosis is regulated by exosomal lncRNA growth arrest-specific 5 (GAS5).[79] In another study, quantitative real-time reverse transcription-polymerase chain reaction (qRT-PCR) and microarray analysis verified the downregulation of SOCS2-AS1in patients with CADs. The gene discussed is GAS5; the disease is atherosclerosis.